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Using the GCRLE grant, Munakata and Namekawa will glimpse additional closely at how oocytes are genomically primed and saved for later on use. They'll look into the position of a chromatin remodeler in oocyte survival and fertility.
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Namekawa believes that in human oocytes, modifications in these styles could disrupt the sensitive choreography of genes being turned on and off at the right moments — leaving them here unprepared for fertilization or growth into healthier embryos. Changes in chromatin framework being an oocyte ages might also impression the way in which that chromosomes segregate through cell division.
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